To investigate the effect of these ABPs in Src-induced proliferation, we first screened for those that affect the pro-growth function of Src in Drosophila, as this organism contains only one family member for each of these ABPs (Supplementary Table 2), reducing the risk of gene redundancy. As expected, distal wing discs overexpressing Drosophila Src oncogene…
Common ABPs are deregulated by Src and in DCIS
To further characterize the mechanisms leading to the transient increase in F-actin and cell stiffness, we searched for ABPs involved in building these F-actin structures. Microarray profiling identified 35 ABPs deregulated during the 36 h of Src-induced cellular transformation (Fig. 3a)18. To test which of these ABPs would be relevant for breast cancer progression, we analysed…
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